Regulatory Variants and Disease: The E-Cadherin −160C/A SNP as an Example

Table 1

Association of E-cadherin −160C/A SNP and diseases.

Disease	Case/control	Ethnicity	Positive association	No association
Gastric cancer	505/246	Italian	[44]
	239/343	Chinese	[59]
	387/392	Chinese	[69]
	107/134	Chinese	[57]
	201/196	Chinese	[70]
	245/950	European	[71]
	39/78	Mexican	[72]
	153/303	Japanese	[73]
	106/90	Japanese	[46]
	53/70	Italian	[74]
	192/170	Omani	[75]
	412/408	Italian		[76]
	572/589	Chinese		[68]
	206/261	Chinese		[77]
	292/146	Korean		[78]
	433/466	Canadian, German, Portuguese		[79]
Prostate cancer	82/188	Dutch	[52]
	1036/669	Swedish	[80]
	183/168	Slovenian	[81]
	200/159	Japanese	[82]
	236/209	Japanese	[83]
	801/1636	Swedish	[84]
	86/126	Caucasian	[9]
	49/117	African American
	219/102	European American	[85]
	119/112	African American		[85]
	89/123	Jamaicans
	98/0	Caucasian		[86]
	219/219	Japanese		[54]
Bladder/urothelial cancer	50/50	Chinese	[8]
	180/100	Chinese	[53]
	314/314	Japanese	[54]
	197/344	Dutch	[55]
	302/0	Caucasian, African American, Hispanic	[56]
Colorectal cancer	194/220	German	[87]
	5679/5412	British	[88]
	130/130	Brazilian	[58]
	505/246	Italian	[44]
	334/171	British		[89]
Pancreatic cancer		Chinese	[90]
Nasopharyngeal cancer	302/140	Tunisian	[60]
Ovarian cancer	207/256	Chinese	[91]
Renal cancer	526/514	Polish		[92]
Lung cancer	95/85	Chinese	[93]
Hepatocellular carcinoma	131/347	Chinese	[94]
	93/0	Chinese		[95]
Benign diseases
Endometriosis	505/246	Italian	[44]
	715/370	Indian	[47]
	511/498	Japanese		[61]
	152/189	Chinese		[96]
Nonsyndromic orofacial clefts (NSOC)	140/107	Chinese	[97]
Asthma	299/383	Asian	[63]
Nephrolithiasis	127/152	Chinese	[64]
PI-IBS	228/581	Caucasians	[65]