Table of Contents
Molecular Biology International
Volume 2015 (2015), Article ID 638515, 6 pages
http://dx.doi.org/10.1155/2015/638515
Research Article

FOXO3a Gene Polymorphism Associated with Asthma in Indian Population

Department of Biotechnology, Sinhgad College of Engineering, Vadgaon Budruk, Pune, Maharashtra 411041, India

Received 25 September 2015; Revised 24 November 2015; Accepted 25 November 2015

Academic Editor: Malayannan B. Subramaniam

Copyright © 2015 Shravani Barkund et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Asthma is a chronic inflammatory disorder delineated by a heightened immunological response due to environmental or genetic factors. Single nucleotide polymorphism studies have shown that FOXO3a plays a pivotal role in maintaining immunoregulation. Polymorphism in FOXO3a has been linked to inflammatory diseases such as chronic obstructive pulmonary disease (COPD), Rheumatoid Arthritis, and Crohn’s disease suggesting that FOXO3a may be associated with asthma. Airway inflammation in asthma is characterized by activation of T helper type 2 (Th2) T cells and Foxo family members are reported to play critical roles in the suppression of T cell activation. Thus this study was undertaken to investigate an association between single nucleotide polymorphism of the FOXO3a (rs13217795, C>T transition) gene and asthma in Indian population. To our knowledge we are the first ones reporting an association between FOXO3a and asthma.