Electrostatic Interactions between Complement Regulator CD46(SCR1-2) and Adenovirus Ad11/Ad21 Fiber Protein Knob

Figure 1

CD46(SCR1-2) and adenovirus protein configuration. (a) Geometric configuration for Ad11k or Ad21k in complex with CD46. Ad11k or Ad21k has three protomers that can bind up to three CD46 molecules, adopting a trimer of dimers conformation. The interactions are homologous for each CD46 molecule. (b) Adenovirus protein binding occurs at the SCR1-SCR2 domains of CD46. Both Ad11k and Ad21k use two protomers, P1 and P2, to bind CD46 at the SCR1 and SCR2 domains. (c) Structure of CD46(SCR1-2)-Ad11k (PDB ID 3O8E). P1 (blue) refers to chain A and P2 (green) refers to chain E of the PDB file. (d) Structure of CD46(SCR1-2)-Ad21k (PDB ID 3L89). P1 (blue) refers to chain B and P2 (green) refers to chain C of the PDB file. In both complexes, P1 buries a greater surface area into CD46(SCR1-2). Molecular graphics were generated using Chimera [28].

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