Electrostatic Interactions between Complement Regulator CD46(SCR1-2) and Adenovirus Ad11/Ad21 Fiber Protein Knob

Figure 2

Electrostatic maps of binding sites for CD46(SCR1-2)-Ad11k (a) and CD46(SCR1-2)-Ad21k (b). Both complexes use localized positive and negative patches for complementary binding. Each panel is an open-book view of each complex, where the left image reflects the right image around the vertical axis. The transparent outlines show the position of the partner protein in the complex. Acidic residues reside in red spots (−3/e) while basic residues reside in blue spots (+3/e). Residues from Table 1 that contribute to distinguishable electrostatic regions are labeled. Ad11k and Ad21k are composed of two different chains, as indicated by the letter in parentheses. Molecular graphics were generated using Chimera [28].

(a)

(b)