Electrostatic Interactions between Complement Regulator CD46(SCR1-2) and Adenovirus Ad11/Ad21 Fiber Protein Knob

Figure 3

Coulombic interaction maps for CD46(SCR1-2)-Ad11k (a) and CD46(SCR1-2)-Ad21k (b). In accordance with Table 1, both complexes have residues that participate in intermolecular Coulombic interactions at the interface. Residues that form only weak interactions are highlighted in purple, while residues that form at least one medium interaction are highlighted in orange. No strong Coulombic interactions are present. Each panel is an open-book view of each complex, where the left image reflects the right image around the vertical axis. The transparent outlines show the position of the partner protein in the complex. Ad11k and Ad21k residues can come from two different chains, as indicated by the letter in parentheses. Molecular graphics were generated using Chimera [28].

(a)

(b)