Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis

Figure 2

Prostate cancer model showing (a) normal prostate, (b) early prostate cancer, and (c) late stage aggressive prostate cancer. High amount of peptides accumulated in the cellular microenvironment facilitates neoplastic transformation and further progression. Excess neuropeptides like bombesin and endothelin-1 (ET-1) as substrate deregulate multiple signalling pathways and make the cancer aggressive and treatment refractory.