Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis

Table 2

Main signalling pathways involved in CD10 mediated malignancies.

Cancer	Signalling pathway	Reference
Prostate cancer	CD10-FAK kinase interaction	[54]
	FGF-2-mediated angiogenesis	[55, 56]
Non-small cell lung cancer	Hypoxia induced stromal CD10 upregulation	[22]
Head and neck squamous cell carcinoma	Increased expression of OCT3/4 by CD10-positive population	[24]
Esophageal squamous cell carcinoma	Twist1 mediated CD10 upregulation	[29]
Prostate cancer	Decreased CD10 expression with high NF-κB expression.	[23]
Prostate cancer	CD10 loss mediated Akt activation	[57]
Colorectal cancer	CD10 overexpression with MUC2 reduced expression	[39]
Leukemias	DNA methylation of promoter region of CD10	[58]