The Effect of Amlodipine on Oxidative Stress in Patients with Type 2 Diabetes

Takebayashi, Kohzo; Naruse, Rika; Aso, Yoshimasa; Inukai, Toshihiko

doi:https://doi.org/10.3814/2010/326840

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Clinical Study | Open Access

Volume 2010 | Article ID 326840 | https://doi.org/10.3814/2010/326840

The Effect of Amlodipine on Oxidative Stress in Patients with Type 2 Diabetes

Kohzo Takebayashi,¹Rika Naruse,¹Yoshimasa Aso,¹and Toshihiko Inukai¹

Received02 Sept 2009

Revised07 Oct 2009

Accepted13 Oct 2009

Published13 Jan 2010

Abstract

Background. Amlodipine, a calcium channel blocker, is reported to have an antioxidative effect in vitro, but whether such an effect occurs clinically is unknown. The purpose of the study was to investigate the effect of amlodipine (5 mg/day) on oxidative stress by measuring urinary 8-iso-prostaglandin F2α (8-iso-PGF2α), an oxidative stress marker, in patients with type 2 diabetes. The anti-oxidative effect of amlodipine was also assessed using the levels of high-sensitivity C-reactive protein (hsCRP) and fibrinogen. Patients and Methods. Seventeen consecutive patients with type 2 diabetes complicated by hypertension were prospectively enrolled in the study. These patients received amlodipine (5 mg/day) over a 3-month period and various markers were measured before and at the end of this period. Results. Urinary 8-iso-PGF2α showed a tendency to decrease, but the change was not statistically significant (P=.1127). The patients were divided into two groups according to the baseline level of urinary 8-iso-PGF2α, and a significant decrease in 8-iso-PGF2α was found in the group (n=9) with a relatively high baseline 8-iso-PGF2α. There were no changes in hsCRP, fibrinogen, and plasminogen activator inhibitor-1. Significant decreases in systolic and diastolic blood pressure were observed (P<.0001, P=.0151, resp.). Conclusion. The results show that amlodipine (5 mg/day) may provide a clinically useful anti-oxidative effect, based on evaluation of urinary 8-iso-PGF2α.

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Copyright

Copyright © 2010 Kohzo Takebayashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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