Table of Contents
SRX Medicine
Volume 2010, Article ID 581923, 3 pages
Case Report

Fatal Mimicry: Oral Melanoma versus Mantle Cell Lymphoma

1OSU Medical Center, USA
2Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada

Received 15 October 2009; Revised 18 January 2010; Accepted 9 February 2010

Copyright © 2010 L. Margolin and A. Monselise. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a 71-year-old male with oral melanoma and mantle cell hyperplasia who was erroneously diagnosed and treated as mantle cell lymphoma. The differential diagnosis of MCL versus mantle cell hyperplasia is a challenging task. Thorough immunohistochemical and cytogenetic analyses are warranted before treatment administration. The more common presentation of amelanotic malignant melanoma requires a high index of suspicion for masses identified in the mouth and requires biopsy for definitive diagnosis. A meticulous physical examination is advocated.