In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [¹⁸F]FAHA and [¹⁸F]FDG PET/CT Imaging

Figure 2

Comparison of tumor [¹⁸F]FAHA values, based on graphical analyses before and after drug administration. [¹⁸F]FAHA values significantly increased in the H441 and PC14 xenografts after administration of cisplatin in Groups A (2 mg/kg cisplatin) and B (4 mg/kg cisplatin), but not in Group C (4 mg/kg cisplatin +300 mg/kg SAHA). Data are . Different superscript letters indicate significant differences (, compared to the values before drug administration; ^a, Group C vs. Group B).

(a)

(b)