Automated Synthesis and Initial Evaluation of (4-Amino-5,8-difluoro-1H-spiro[piperidine-4,2-quinazolin]-1-yl)(4-[¹⁸F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Figure 1

(a) Radiosynthesis scheme of (4-amino-5,8-difluoro-1H-spiro[piperidine-4,2-quinazolin]-1-yl)(4-[¹⁸F]fluorophenyl)methanone ([¹⁸F]FBAT). (b) Diagram of the automated robotic system for the radiosynthesis of [¹⁸F]FBAT. Solid circle: one-way magnetic valve; open circle: two-way magnetic valve. Eluent 1: CH₂Cl₂; eluent 2: CH₂Cl₂/CH₃OH(3/2); vial 1: labeling vial; vial 2: hydrolysis vial; vial 3: product vial.

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