Automated Synthesis and Initial Evaluation of (4-Amino-5,8-difluoro-1H-spiro[piperidine-4,2-quinazolin]-1-yl)(4-[¹⁸F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Figure 2

The LPS- and LPS+ AMG-induced iNOS expression and NO production. (a) NO production in the presence of different concentrations of LPS. (b) Time-dependent uptake of [¹⁸F]FBAT. Control BV2 cells (black line), LPS-induced BV2 cell (red line), and LPS-induced BV2 cell pretreated with 1 mM (blue line) or 0.1 mM aminoguanidine (green line). (c) NO production in control cell, cell treated with LPS, and cell pretreated with 1 mM or 0.1 mM aminoguanidine before LPS treatment. Data are ( per group). compared to controls; ^## compared to the LPS 3 h group.

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