Automated Synthesis and Initial Evaluation of (4-Amino-5,8-difluoro-1H-spiro[piperidine-4,2-quinazolin]-1-yl)(4-[¹⁸F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Figure 7

Time activity curves for each region of interest within the brain over 30 min of dynamic PET images. PET imaging showed rapid accumulation of [¹⁸F]FBAT in control or LPS-induced mice. The level of [¹⁸F]FBAT accumulation was significant in the whole brain, cortex, and brainstem at 3 h postinjection of LPS whereas no different accumulation after 24 h LPS induction. In contrast to the whole brain and cortex, there was similar [¹⁸F]FBAT accumulation in the cerebellum before and after treatment with LPS. The accumulated radioactivity is expressed in the unit of SUV. Data are of the voxel values within each ROI ( per group).