Automated Synthesis and Initial Evaluation of (4-Amino-5,8-difluoro-1H-spiro[piperidine-4,2-quinazolin]-1-yl)(4-[¹⁸F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Figure 9

Standard uptake values (SUV), area under the curve (AUC_0-30min), or volume distribution () of [¹⁸F]FBAT. (a) Accumulated radioactivity is expressed in SUV at 20-30 min postinjection of [¹⁸F]FBAT. (b) Dynamitic time activity curves (0-30 min) were used to determine the AUC_0-30min for all scans. (c) Volume distribution (, mL/cm³) of [¹⁸F]FBAT determined by Logan model-independent graphical analysis. Data are ; , , and compared to the controls; ^#, ^##, and ^### compared to the LPS 3 h group.

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(b)

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