Research Article
Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [18F]FEPPA: A Feasibility Study
Table 4
Synthesis of the [18F]FEPPA (2) via various methods.
| References | Radiofluorination condition | RCY (%, EOB) | Synthesis time (min) | Number of production | Molar activity (GBq/μmol) | Automate synthesizer | QC (EP or USP) | TLC | Precursor weight (mg) | Solvent (mL) | Temperature (°C) | Time (min) |
| Wilson et al. [43] | 5 | MeCN 0.7 mL | 90 | 10 | 71–85 | 40–50 | — | 44~100 | — | — | — | Vasdev et al. [58] | 5 | MeCN 0.75 mL | 90 | 10 | | | 54 | | FxFN | — | — | Berroterán-Infante et al. [73] | 3.125 | MeCN 0.5 mL | 90 | 10 | | 30 | 15 | | Nuclear Interface | EP | Y | Vignal et al. [42] | 5 | MeCN 1 mL | 90 | 10 | | 55 | 17 | | AllInOne® | — | — | Zammit et al. [59] | 2 | MeCN 0.4 mL | 90 | 10 | | | — | | CPCU | — | — | Chang et al. [74] | 5 | MeCN 0.6 mL | 90 | 10 | 50 | 80 | 8 | 149~217 | Eckert-Ziegler modular system | — | — | This study | 5 | MeCN 1 mL | 70 | 20 | | | 17 | | FxFN | USP | Y |
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No TLC data were provided. |