Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [¹⁸F]FEPPA: A Feasibility Study

Table 4

Synthesis of the [¹⁸F]FEPPA (2) via various methods.

References	Radiofluorination condition				RCY (%, EOB)	Synthesis time (min)	Number of production	Molar activity (GBq/μmol)	Automate synthesizer	QC (EP or USP)	TLC
	Precursor weight (mg)	Solvent (mL)	Temperature (°C)	Time (min)
Wilson et al. [43]	5	MeCN; 0.7 mL	90	10	71–85	40–50	—	44~100	—	—	—
Vasdev et al. [58]	5	MeCN; 0.75 mL	90	10			54		FxFN	—	—
Berroterán-Infante et al. [73]	3.125	MeCN; 0.5 mL	90	10		30	15		Nuclear Interface	EP	Y
Vignal et al. [42]	5	MeCN; 1 mL	90	10		55	17		AllInOne®	—	—
Zammit et al. [59]	2	MeCN; 0.4 mL	90	10			—		CPCU	—	—
Chang et al. [74]	5	MeCN; 0.6 mL	90	10	50	80	8	149~217	Eckert-Ziegler modular system	—	—
This study	5	MeCN; 1 mL	70	20			17		FxFN	USP	Y

No TLC data were provided.