Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors

Table 4

Summary of PSMA-targeted imaging in prostate cancer brain metastases.

Authors	Year		PSMA tracer	Main results
Chakraborty et al.	2015	1	^68Ga-PSMA	(i) Asymptomatic, avid ^68Ga-PSMA uptake in 3 separate brain metastases, confirmed by MRI
Dureja et al.	2017	1	^68Ga-PSMA	(i) Asymptomatic, ^68Ga-PSMA uptake in 4 brain metastases (SUVmax 4.0), confirmed by MRI
Langsteger et al.	2017	1	^68Ga-PSMA	(i) Asymptomatic, ^68Ga-PSMA uptake in T4-T10 spinal cord metastases, confirmed by MRI
Chan et al.	2017	1	^68Ga-PSMA	(i) Symptomatic, ^68Ga-PSMA uptake in single cerebellar metastasis (SUVmax 5.9), confirmed by pathology
Ross et al.	2020	1	^68Ga-PSMA	(i) Asymptomatic, single brain metastasis detected with ^68Ga-PSMA but not with standard imaging, confirmed by pathology
Yin et al.	2019	1	^68Ga-PSMA	(i) Asymptomatic, ^68Ga-PSMA uptake in multiple brain metastases (SUVmax 3-11) and not all detected on MRI, confirmed by pathology
Wei et al.	2017	2	^68Ga-PSMA	(i) Distinct ^68Ga-PSMA uptake in cerebral metastases; (ii) Decreased uptake as lesion regressed posttherapy
Sathekge et al.	2019	1	^68Ga-PSMA	(i) Several cerebral metastases avidly showed ^68Ga-PSMA uptake; (ii) Size and ^68Ga-PSMA uptake decreased posttherapy
McBean et al.	2021	8	^68Ga-PSMA	(i) 3/8 presented with neurological symptoms; (ii) 4/8 had previously undergone ^177Lu-PSMA therapy; (iii) PSMA avidity ranged from not avid to intense, and SUVmax ranged 2-21
Parihar et al.	2021	1	^68Ga-PSMA	(i) ^68Ga-PSMA uptake in new brain metastases, after ^177Lu-PSMA and ^225Ac-PSMA therapy