Review Article
Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors
Table 5
Summary of PSMA-targeted imaging in nonprostate cancer brain metastases.
| | Authors | Year | | Primary lesion | PSMA tracer | Main results |
| | Medina-Ornelas et al. | 2017 | 1 | Breast | 68Ga-PSMA | (i) Symptomatic, brain metastasis showed 68Ga-PSMA uptake, confirmed by pathology | | Malik et al. | 2018 | 1 | Breast | 68Ga-PSMA | (i) Cerebella metastasis avidly showed 68Ga-PSMA uptake but not FDG | | Marafi et al. | 2020 | 1 | Breast | 68Ga-PSMA | (i) Intense 68Ga-PSMA uptake in cerebral and cerebella metastases, confirmed by MRI
(ii) No uptake in normal brain tissue | | Arslan et al. | 2021 | 1 | Breast | 68Ga-PSMA | (i) Avid 68Ga-PSMA uptake but low FDG uptake in recurrent brain metastasis, confirmed by pathology | | Rowe et al. | 2015 | 1 | Kidney | 18F-DCFPyL | (i) Intense 18F-DCFPyL uptake in brain metastasis (SUVmax 3.9), confirmed by MRI | | Yin et al. | 2019 | 1 | Kidney | 18F-DCFPyL | (i) 18F-DCFPyL uptake in 3 brain metastases (SUVmax 0.5-3.4), confirmed by imaging | | Hod et al. | 2017 | 1 | Melanoma | 68Ga-PSMA | (i) Unexpected avid 68Ga-PSMA uptake in brain metastasis, confirmed by pathology | | Matsuda et al. | 2018 | 1 | Lung | 89Zr-Df-IAB2M | (i) Avid 89Zr-Df-IAB2M uptake corresponding to MRI lesion, confirmed by pathology
(ii) No uptake in normal brain tissue |
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