Preclinical Evaluation of an Activity-Based Probe for Intraoperative Imaging of Esophageal Cancer

<div>Structure, optical properties, and mechanism of action of VGT-309. (a). VGT-309 consists of a cathepsin-targeted PMK electrophile coupled to an ICG fluorophore and QC-1 quencher. Its maximum absorption and emission wavelengths are 745 nm and 820 nm, respectively. (b). Mechanism of action of VGT-309. The ICG fluorophore is quenched by the QC-1 quencher until it is cleaved upon covalent binding by cysteine cathepsins.</div>

Molecular Imaging

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Figure 1

Figure 1: Preclinical Evaluation of an Activity-Based Probe for Intraoperative Imaging of Esophageal Cancer 