Preclinical Evaluation of an Activity-Based Probe for Intraoperative Imaging of Esophageal Cancer

<div>Esophageal carcinoma cell lines express cathepsins that are fluorescently labeled by VGT-309. (a). Western blot analysis of cathepsin expression in esophageal cancer cell lines with KB (human cervical carcinoma) used as a positive control. (b). SDS-PAGE analysis of probe-labeled species in OE19 (human esophageal adenocarcinoma) cells with and without pretreatment with 100 <i>μ</i>M JPM-OEt, a broad spectrum cathepsin inhibitor.</div>

Molecular Imaging

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Figure 2

Figure 2: Preclinical Evaluation of an Activity-Based Probe for Intraoperative Imaging of Esophageal Cancer 