Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis

Figure 10

UC Berkeley MPI images show the EPR effect in breast cancer (MDA-MB231) tumor model in an athymic rat [38] (a) Tracer dynamics: rim enhancement followed by EPR and cellular uptake and washout. (MPI images are coregistered with X-ray images for anatomical reference.) (Adapted with permission from Yu et al., Nano Letters, 2017. Copyright (2017) American Chemical Society [38]) (b) Iron and rat macrophage colocalization histology: side-by-side comparison of identical tissue sections stained with Prussian blue and CD68 shows iron-laden macrophages (blue) present in the central stroma of the xenograft that is positive for macrophage marker CD68 (brown).

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