Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis

Figure 8

Kinetic models from scintigraphy and PET studies can be directly adopted for use with MPI. The most common model of irreversible tracer uptake or the Patlak model was used to quantify the rate of gut (GI tract) bleeding using MPI in a murine model. The approach assumes (a) a central compartment consisting of the tracers in the circulation from which C_p(t) can be calculated from the MPI signal from the ventricle of the heart and a peripheral compartment in which the tracer enters irreversibly at the rate constant k_bleed. (b) The slope of the rate equation from the graph can be used to estimate the rate of bleeding. (c) Dynamic MPI images show the central compartment (heart) and the peripheral bleed compartment (GI tract) (MPI images are overlayed on X-ray projection data (grayscale) for anatomical reference). (Adapted with permission from Yu et al., ACS Nano, 2017. Copyright (2017) American Chemical Society) [27].

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