Accuracy of an Immunochromatographic Diagnostic Test (ICT Malaria Combo Cassette Test) Compared to Microscopy among under Five-Year-Old Children when Diagnosing Malaria in Equatorial Guinea

Table 1

Sensitivity and specificity of the ICT test compared to microscopy by Plasmodium falciparum monoinfection and parasitemia ranges.

Parasites/𝜇l	N*	Sn	Sp	PPV	NPV	LR+	LR−	AUC
<101	27	33.3 (54.0–16.5)^#	88.8 (92.2–84.4)	22.5 (38.5–10.8)	93.2 (95.9–89.4)	2.9 (5.6–1.6)	0.7 (0.9–0.6)	0.6 (0.7–0.5)
101–500	4	50.0 (93.2–6.7)	88.3 (83.9–91.8)	5.8 (19.7–0.7)	99.2 (99.9–97.1)	4.3 (12–1.5)	0.5 (1.5–0.2)	0.7 (0.9–0.4)
>500	35	100.0 (100.0–90.0)	73.8 (78.5–68.7)	29.2 (38.2–21.2)	100.0 (100.0–98.5)	3.8 (4.6–3.2)	0	0.8 (0.9–0.8)

Sn:  sensitivity.
Sp: specificity.
PPV: positive predictive value.
NPV: negative predictive value.
LR+: Likelihood Ratio of positive test.
LR−: Likelihood Ratio of negative test.
AUC: Area Under the Receiver Operator Characteristic Curve.
*Number of individuals with monoinfection by Plasmodium falciparumin each parasitemia group.
^#All values in brackets indicate 95% Confidence Intervals.