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Malaria Research and Treatment
Volume 2010, Article ID 973094, 9 pages
Review Article

The Survival Strategies of Malaria Parasite in the Red Blood Cell and Host Cell Polymorphisms

Regional Medical Research Centre, Indian Council of Medical Research, Chandrasekharpur, Bhubaneswar 751023, India

Received 4 May 2010; Accepted 7 July 2010

Academic Editor: Mats Wahlgren

Copyright © 2010 Gunanidhi Dhangadamajhi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Parasite growth within the erythrocyte causes dramatic alterations of host cell which on one hand facilitates nutrients acquisition from extracellular environment and on other hand contributes to the symptoms of severe malaria. The current paper focuses on interactions between the Plasmodium parasite and its metabolically highly reduced host cell, the natural selection of numerous polymorphisms in the genes encoding hemoglobin and other erythrocyte proteins.