In Vitro Antiplasmodial Activity and Cytotoxicity of Extracts of Selected Medicinal Plants Used by
Traditional Healers of Western Cameroon
Table 2
Antiplasmodial activity and cytotoxicity of the tested products.
Scientific name (Family)
Part used (Code)
IC50 on 3D7 (g/mL)
IC50 on DD2 (g/mL)
CC50 on LLC/MK2 (g/mL)
SI on 3D7 (SI on DD2)
Cuviera longiflora
Leaves (CLL)
20.24 ± 4.95
13.91 ± 0.65
250
12.35 (17.91)
Dacryodes edulis (Burseraceae)
Leaves (DEL)
6.45 ± 0.88
8.62 ± 1.44
>1000
ND
Eucalyptus globulus
Leaves (EGL)
16.80 ± 8.35
26.45 ± 3.32
208.33
12.40 (7.88)
Kotschya speciosa
Whole plant (KS)
48.29 ± 4.46
108.89 ± 17.21
>1000
ND
Aerial part (KSH)
22.61 ± 10.34
ND
625
27.64
Aerial part (KSR)
64.30 ± 12.76
59.30 ± 8.32
>1000
ND
Coula edulis
Stem bark (CE)
13.80 ± 3.25
5.79 ± 1.33
178.57
12.94 (30.84)
Vernonia amygdalina
Leaves (VAL)
8.72 ± 2.11
11.27 ± 2.06
>1000
ND
Root bark (VAR)
9.01 ± 1.11
ND
>1000
ND
Vismia guinensis
Stem bark (VGE)
43.42 ± 2.76
4.735 ± 3.54
>1000
ND
Stem bark (VGS)
65.29 ± 7.58
62.5 ± 12.45
>1000
ND
Chloroquine
0.10
0.95 ± 0.01
—
—
IC50: inhibition 50%, CC50: cytotoxic concentration 50%, each value represents the average and standard deviation obtained from 6 different measurements; ND: not determined.
