Subacute Therapeutic Dosing of Artemether-Lumefantrine and Artesunate-Amodiaquine Combination Preserves Plasma Cholesterol, Renal Antioxidant Status, and Organ Weights in Rats

Table 1

Effects of artemether-lumefantrine and artesunate-amodiaquine combination on renal antioxidants and lipid peroxidation levels in rats.

Treatments	CAT^a	SOD^b	GST^c	GSH^c	MDA^d
Control	0.153±0.01	0.24±0.06	0.64±0.03	0.022±0.001	0.017±0.002
A+L	0.160±0.01	0.50±0.21	0.63±0.03	0.021±0.001	0.030±0.002^∗
(1.14/6.86 mg/kg/d)	(−4.6)^a	(−108.3)^a	(1.6)^a	(4.5)^a	(−76.5)^a
A+A	0.170±0.02	0.95±0.04	0.49±0.07	0.091±0.065	0.031±0.006^∗
(2.86/8.58 mg/kg/d)	(−11.1)^a	(−295.8)^a	(23.4)^a	(−313.6)^a	(−82.4)^a

Results expressed as mean ±SEM. Values in parenthesis represent % change; (−): increase; (+): decrease, (a) % change relative to control group. ^∗𝑃<0.05 when compared with control. ^aExpressed as units in μmol/mL/mg protein; ^bactivity expressed as units/mg protein; ^cactivity expressed as nmoles/mg protein; ^dconcentration expressed as nmoles/mg protein; A+L: artemether + lumefantrine; A+A: artesunate + amodiaquine; CAT: catalase, SOD: superoxide dismutase, GST: glutathione s-transferase; GSH: total glutathione, MDA: malondialdehyde.