Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon

Table 2

Responses to CQ/PQ treatment, CQ blood levels and genotyping analysis from patients with recurrence of parasitemia.

Patient no.	Parasitologic response*	Therapeutic response^†	CQ levels in blood (ng/mL)			D-0 versus D-R genotype
			CQ	DCQ	Total CQ
PC046	RI (late)	LPF	21	43	64	Different
SJ004	RI (late)	LPF	BD**	23	23	Different
SC058	RI (late)	LPF	36	BD**	36	Same
SC105	RI (late)	LCF	42	53	95	Same

*RI (late), parasitological response, World Health Organization resistance levels, (Bruce-Chwatt, 1986).
^†Only as reference: this classification is no longer used for P. vivax; World Health Organization; Peter Bloland; 2003.
**BD: below the limit of detection (<10 ng/mL).