Malaria Research and Treatment / 2013 / Article / Fig 4

Clinical Study

Amodiaquine-Artesunate versus Artemether-Lumefantrine against Uncomplicated Malaria in Children Less Than 14 Years in Ngaoundere, North Cameroon: Efficacy, Safety, and Baseline Drug Resistant Mutations in pfcrt, pfmdr1, and pfdhfr Genes

Figure 4

(a) and (b) show the prevalence of haplotypes of the dhfr and pfcrt genes in Ngaoundere, a savannah region in the north of Cameroon. IRN represents the fansidar resistance conferring mutant in the dhfr gene, NCS represent the wild type haplotype, and mixed haplotype is also represented. These haplotypes were built based on the presence of absence of mutation in codon 76 of the pfcrt gene (a) or cumulative mutations at codons 51, 59, and 108 of the dhfr gene (b).
(a) Prevalence of pfcrt haplotypes in Ngaoundere, North Cameroon. Haplotypes in our analysis involved codons at positions 72–76 of the pfcrt gene
(b) Baseline prevalence of some haplotypes in the pfcrt and dhfr genes in Ngaoundere

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