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Malaria Research and Treatment
Volume 2013, Article ID 341862, 5 pages
Research Article

Clinical Manifestations, Treatment, and Outcome of Hospitalized Patients with Plasmodium vivax Malaria in Two Indian States: A Retrospective Study

1Department of Pharmacology, Government Medical College and Hospital, Chandigarh 160035, India
2Department of Pharmacology, GMERS Medical College, Sola, Ahmedabad, Gujarat 382012, India
3Department of Pharmacology, Surat Municipal Institute of Medical Sciences & Research (SMIMER), Surat, Gujarat 395010, India
4National Institute of Research in Reproductive Health, Parel, Mumbai 400012, India
5ESI-PGIMSR & MGM Hospital, Parel, Mumbai 400012, India
6National Chair Clinical Pharmacology, Indian Council of Medical Research, ESI-PGIMSR & MGM Hospital, Parel, Mumbai 400012, India

Received 30 September 2013; Revised 4 December 2013; Accepted 10 December 2013

Academic Editor: Rana Chattopadhyay

Copyright © 2013 Jagjit Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This was a retrospective study done on 110 patients hospitalized with P. vivax malaria in three medical college hospitals, one in the union territory of Chandigarh and the other two in Gujarat, that is, Ahmedabad and Surat. The clinical presentation, treatment, and outcome were recorded. As per WHO criteria for severity, 19 of 110 patients had severe disease—six patients had clinical jaundice with hepatic dysfunction, three patients had severe anemia, three had spontaneous bleeding, two had acute respiratory distress syndrome, and one had cerebral malaria, hyperparasitemia, renal failure, circulatory collapse, and metabolic acidosis. All patients with severe P. vivax malaria survived, but one child with cerebral malaria had neurological sequelae. There was wide variation in the antimalarial treatment received at the three centres. Plasmodium vivax malaria can no longer be considered a benign condition. WHO guidelines for treatment of P. vivax malaria need to be reinforced.