Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity
Figure 2
(a) Decoquinate, a 4-hydroxyquinoline (ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinecarboxylate), C24H35NO5, molecular weight 417.54, CAS Number 18507-89-6; it is poorly soluble in water (0.06 mg/L in purified water and <0.01 mg/L in buffered water pH 4–9). (See [9]). (b) WR 299666, (E)-1-(3, 4-dichlorophenyl)-3-(1-methyl-4, 5-dioxoimidazolidin-2-ylidene) guanidine, C11H9Cl2N5O2, molecular weight 314.13.
