Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

Table 2

Particle size (μm) measurements of W299666 in water or HECT suspension stored at 4°C.

Stability duration	Methods
	Grinder	HG	US	HPH
Week 1	42.54	66.31	1.52	0.376
Week 2	41.07	71.85	1.58	0.397
Week 3	43.05	47.49	1.41	0.445
Mean	42.22	61.88	1.50	0.406

HG: homogenizer with generator; US: ultra-sonicator; HPH: high pressure homogenization.