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Malaria Research and Treatment
Volume 2014, Article ID 372521, 10 pages
http://dx.doi.org/10.1155/2014/372521
Clinical Study

Single Ascending Dose Safety and Pharmacokinetics of CDRI-97/78: First-in-Human Study of a Novel Antimalarial Drug

1Department of Pharmacology, PGIMER, Chandigarh, India
2Pharmacokinetics and Metabolism Division, Central Drug Research Institute, Lucknow, India
3IPCA Laboratories Ltd., Mumbai, Maharashtra, India
4Department of Internal Medicine, PGIMER, Chandigarh, India
5Department of Anaesthesia Incharge, Critical Care, PGIMER, Chandigarh, India
6Clinical and Experimental Medicine, Central Drug research Institute, Lucknow, India

Received 14 November 2013; Revised 13 January 2014; Accepted 17 January 2014; Published 27 March 2014

Academic Editor: Neena Valecha

Copyright © 2014 N. Shafiq et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Yeshwant Singh, Mahendra Kumar Hidau, Jampala Krishna, and Shio Kumar Singh, “Combined effect of rifampicin-induced P-glycoprotein expression and lipopolysaccharide-induced intestinal sepsis on the effective permeability and pha,” Xenobiotica, vol. 45, no. 8, pp. 731–740, 2015. View at Publisher · View at Google Scholar
  • Yeshwant Singh, Mahendra Kumar Hidau, and Shio Kumar Singh, “Rifabutin reduces systemic exposure of an antimalarial drug 97/78 upon co- administration in rats: an in-vivo & in-vitro analysis,” Asian Pacific Journal of Tropical Medicine, 2015. View at Publisher · View at Google Scholar
  • Timothy N. C. Wells, Rob Hooft van Huijsduijnen, and Wesley C. Van Voorhis, “Malaria medicines: a glass half full?,” Nature Reviews Drug Discovery, vol. 14, no. 6, pp. 424–+, 2015. View at Publisher · View at Google Scholar
  • Muhammad Wahajuddin, Sheelendra P. Singh, Isha Taneja, Kanumuri S. R. Raju, Jiaur R. Gayen, Hefazat H. Siddiqui, and Shio K. Singh, “Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS met,” Malaria Journal, vol. 14, 2015. View at Publisher · View at Google Scholar
  • Muhammad Wahajuddin, Sheelendra Pratap Singh, Isha Taneja, Kanumuri Siva Rama Raju, Jiaur Rahman Gayen, Hefazat Hussain Siddiqui, and Shio Kumar Singh, “Development and validation of an LC-MS/MS method for simultaneous determination of piperaquine and 97-63, the active metabolite of CDRI 97-78, in rat ,” Drug Testing And Analysis, vol. 8, no. 2, pp. 221–227, 2016. View at Publisher · View at Google Scholar
  • Elizabeth A. Ashley, and Aung Pyae Phyo, “Drugs in Development for Malaria,” Drugs, 2018. View at Publisher · View at Google Scholar