Pharmacokinetic Study and Bioavailability of a Novel Synthetic Trioxane Antimalarial Compound 97/63 in Rats

Table 3

Pharmacokinetic parameter of 97/63 after oral administration at 72 mg kg⁻¹ and intravenous administration at 18 mg kg⁻¹ dose of 97/63 in male rats (mean ± SD, ).

PK parameter	Oral	Intravenous
(ng mL^−1)	*	1799.99 ± 330.24
(ng mL^−1)	229.24 ± 64.26	*
(h)	1.00 ± 0.7	*
(α) (h)	0.84 ± 0.14	0.45 ± 0.08
(β) (h)	10.61 ± 0.2	10.57 ± 0.16
(ng h mL^−1)	1268.97 ± 27.04	2025.75 ± 574.3
Vd (L kg^−1)	172.31 ± 28.59	134.7 ± 11.17
Cl (L h^−1 Kg^−1)	11.2 ± 0.07	8.89 ± 0.11
% bioavailability	15.66	—

Not applicable.