Role of Different Pfcrt and Pfmdr-1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum

Table 1

List of plausible mutations in pfmdr-1 of Plasmodium falciparum along with properties of both substituent and substituted amino acids.

Site of mutation	Substituted amino acids	Polarity	Side chain charge	Hydrophobicity index	Substituent amino acid	Side chain polarity	Side chain charge	Hydrophobicity index
86	Asparagine	Polar	Neutral		Tyrosine	Polar	Neutral
1042	Asparagine	Polar	Neutral		Aspartic acid	Acidic polar	Negative
1034	Serine	Polar	Neutral		Cystien	Non polar	Neutral
1246	Aspartic acid	Acidic polar	Negative		Tyrosine	Polar	Neutral