Nonobese Diabetic (NOD) Mice Lack a Protective B-Cell Response against the “Nonlethal” Plasmodium yoelii 17XNL Malaria Protozoan

Figure 2

Anti-iRBCs B-cell responses in the P. yoelii 17XNL-infected NOD and C57BL/6 mice. (a) Antibody titers in individual mice from P. yoelii-infected NOD mice and C57BL mice by immunofluorescence (IFA) 14 days after infection; (b) sera from the same individual mice analyzed at the same time points as in (a) for the IgG1, or IgG2b, or IgG2c, or IgG3 titers specific for iRBCs. -axis shown in both (a) and (b) represents the serum serial dilutions tested in IFA. Of note, only specific IgG2c antibodies were detected in the blood of C57BL/6 mice, but not in NOD-infected mice. The results were collected from each strain of mice ( mice/group/strain).

(a)

(b)