Sustained Effectiveness of a Fixed-Dose Combination of Artesunate and Amodiaquine in 480 Patients with Uncomplicated Plasmodium falciparum Malaria in Côte d’Ivoire
Table 1
Patient characteristics at inclusion.
Period 1
Period 2
value
= 288
= 286
Age (years)
Mean ± SD
5.35 ± 7.63
4.17 ± 4.03
0.483
Median [range]
3 [0.4–62.2]
3.1 [0.3–36.7]
Children under five years of age
201 (69.8%)
217 (75.9%)
0.101
Gender
0.244
Female
131 (45.5%)
144 (50.3%)
Male
157 (54.5%)
142 (49.7%)
Weight (kg)
0.639
Mean ± SD
16.2 ± 11.7
14.8 ± 8.6
Median [range]
12 [6–71]
12 [5–63]
Clinical signs and symptoms
Fever1
288 (100%)
286 (100%)
0.163
Asthenia/weakness
241 (83.7%)
234 (81.8%)
0.555
Chills
63 (21.9%)
122 (42.7%)
<0.001
Perspiration
230 (79.9%)
225 (78.7%)
0.725
Headache2
61/77 (79.2%)
39/48 (81.3%)
0.783
Pain
18 (6.3%)
25 (8.7%)
0.257
Dizziness2
5/73 (6.8%)
7/48 (14.6%)
0.164
Nausea2
17/77 (22.1%)
12/48 (25.0%)
0.707
Decreased appetite/anorexia
241 (83.7%)
233 (81.5%)
0.485
Parasitaemia
Positive thick blood smears1
288 (100%)
286 (100%)
NA
Mean parasite density (/μl)
41.6 ± 45.5 (×103)
71.1 ± 85.5 (×103)
<0.001
Gametocyte carriers
7 (2.4%)
5 (1.7%)
0.568
Mean gametocyte density (/μl)
47.1 ± 70.9
967.8 ± 1290.9
0.051
The presence of fever and a positive thick blood smear were obligate inclusion criteria. 2Certain symptoms documented from self-report, such as nausea, headache, and dizziness could not be ascertained in young infants.
