Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

Figure 2

Representative in vivo bioluminescent images of C3H mice shown at different time points after injection of 10,000 sporozoites. Rainbow images show the relative levels of luminescence ranging from low (blue), to medium (green), to high (yellow/red). Luminescence levels (photons/sec) of livers in whole mice at 24-, 48- (liver stage), and 72-hour (blood stage) time points following single intramuscular dosing treated with IM-DQ in macrosuspension at a MCD₁₀₀ dose of 120 mg/kg 8 weeks prior to malaria infection (8 W, left) and oily vehicle control (VC, right) after sporozoite infection intravenously at day 0. Normally, P. berghei sporozoites reside in the mouse liver for 44–52 hours after infection ().