Table of Contents Author Guidelines Submit a Manuscript
Malaria Research and Treatment
Volume 2017 (2017), Article ID 7508291, 10 pages
https://doi.org/10.1155/2017/7508291
Research Article

Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

Military Malaria Research Program, Walter Reed Army Institute of Research, Experimental Therapeutics Branch, Silver Spring, MD, USA

Correspondence should be addressed to Qigui Li; lim.liam@vic.il.iugiq

Received 26 October 2016; Accepted 31 January 2017; Published 13 April 2017

Academic Editor: Donatella Taramelli

Copyright © 2017 Qigui Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Wang, Q. Li, S. Reyes et al., “Formulation and particle size reduction improve bioavailability of poorly water-soluble compounds with antimalarial activity,” Malaria Research and Treatment, vol. 2013, Article ID 769234, 10 pages, 2013. View at Publisher · View at Google Scholar
  2. F. P. Da Cruz, C. Martin, K. Buchholz et al., “Drug screen targeted at plasmodium liver stages identifies a potent multistage antimalarial drug,” Journal of Infectious Diseases, vol. 205, no. 8, pp. 1278–1286, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. T.-G. Nam, C. W. McNamara, S. Bopp et al., “A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor,” ACS Chemical Biology, vol. 6, no. 11, pp. 1214–1222, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Wang, Q. Li, S. Reyes et al., “Nanoparticle formulations of decoquinate increase antimalarial efficacy against liver stage Plasmodium infections in mice,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 10, no. 1, pp. 57–65, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. A. C. Anselmo and S. Mitragotri, “An overview of clinical and commercial impact of drug delivery systems,” Journal of Controlled Release, vol. 190, pp. 15–28, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. Q. Li, M. O'Neil, L. Xie et al., “Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections,” Malaria Journal, vol. 13, no. 1, article no. 141, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Xie, Q. Li, J. Johnson, J. Zhang, W. Milhous, and D. Kyle, “Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria,” Parasitology, vol. 134, no. 9, pp. 1151–1162, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. Li, L. Gerena, L. Xie, J. Zhang, D. Kyle, and W. Milhous, “Development and validation of flow cytometric measurement for parasitemia in cultures of P. falciparum vitally stained with YOYO-1,” Cytometry A, vol. 71, no. 5, pp. 297–307, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. J. M. Andrews, “Determination of minimum inhibitory concentrations,” Journal of Antimicrobial Chemotherapy, vol. 48, no. 1, pp. 5–16, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. I. H. J. Ploemen, M. Prudêncio, B. G. Douradinha et al., “Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging,” PLoS ONE, vol. 4, no. 11, Article ID e7881, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Thiberge, S. Blazquez, P. Baldacci et al., “In vivo imaging of malaria parasites in the murine liver,” Nature Protocols, vol. 2, no. 7, pp. 1811–1818, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. N. J. White, “Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization,” Antimicrobial Agents and Chemotherapy, vol. 57, no. 12, pp. 5792–5807, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. M. M. Mota, G. Pradel, J. P. Vanderberg et al., “Migration of Plasmodium sporozoites through cells before infection,” Science, vol. 291, no. 5501, pp. 141–144, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. J. F. G. M. Meis, J. P. Verhave, P. H. K. Jap, and J. H. E. T. Meuwissen, “Transformation of sporozoites of Plasmodium berghei into exoerythrocytic forms in the liver of its mammalian host,” Cell and Tissue Research, vol. 241, no. 2, pp. 353–360, 1985. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Leng, H. Chen, G. Li et al., “Development and comparison of intramuscularly long-acting paliperidone palmitate nanosuspensions with different particle size,” International Journal of Pharmaceutics, vol. 472, no. 1-2, pp. 380–385, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Simon, V. R. De Almeida Borges, L. M. Cabral, and V. P. De Sousa, “Development and validation of a discriminative dissolution test for betamethasone sodium phosphate and betamethasone dipropionate intramuscular injectable suspension,” AAPS PharmSciTech, vol. 14, no. 1, pp. 425–434, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. H. F. Salem, “Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats,” International Journal of Nanomedicine, vol. 5, no. 1, pp. 943–954, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. MacGowan, “Revisiting Beta-lactams—PK/PD improves dosing of old antibiotics,” Current Opinion in Pharmacology, vol. 11, no. 5, pp. 470–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Fortin, M. M. Stevenson, and P. Gros, “Complex genetic control of susceptibility to malaria in mice,” Genes and Immunity, vol. 3, no. 4, pp. 177–186, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Hernandez-Valladares, P. Rihet, and F. A. Iraqi, “Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes,” Physiological Genomics, vol. 46, no. 1, pp. 1–16, 2014. View at Publisher · View at Google Scholar · View at Scopus