Malaria Research and Treatment / 2017 / Article / Tab 3

Research Article

Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

Table 3

Main pharmacokinetic parameters of decoquinate in oily suspension with nano- and microparticle following single intramuscular injection at 120 mg/kg dose level in mice liver ( = 2-3).

Main PK parameters following IM injectionNano-DQ (0.43 µm)
liver
CV%Micro-DQ (8.31 µm)
liver
CV%

(ng/g)114.63 ± 7.196.27455.29 ± 46.0310.11
(hr)3.36 ± 0.133.862.85 ± 0.3913.68
(ng⋅hr/g)127,674 ± 2,4751.94156,410 ± 15,0769.64
(hr)3.14 ± 0.278.591.98 ± 0.5125.76
(hr)861.16 ± 22.402.601,421.00 ± 40.262.83

MIC at 1,344 h (ng/ml)47.35 ± 5.1710.93

Value was calculated based on full causal prophylaxis effect for 8 weeks. IM: intramuscular; DQ: decoquinate.

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