Influence of Gold Nanoparticle Shape and Single-Cell Localization on Energy Deposition Efficiency and Irradiation Specificity in Photon Radiotherapy

Figure 4

Influence of AuNP shape. Graphs show the dependence of the relative usable fraction of deposited energy with respect to spherical AuNPs Δⁱ (i = rod, plate) on the photon beam energy for nanoparticle concentrations of (a) 1 (mg Au)/(g H₂O), (b) 7 (mg Au)/(g H₂O), and (c) 20 (mg Au)/(g H₂O). At each concentration, red graphs pertain to gold nanoplates and blue graphs to gold nanorods, while different lines of the same color (solid, dashed, and dotted) refer to three diameters of gold nanospheres (100, 50, and 10 nm, respectively). Nanorods and nanoplates were of the same volume as the nanospheres.

(a)

(b)

(c)