Roles of Integrins and Intracellular Molecules in the Migration and Neuritogenesis of Fetal Cortical Neurons: MEK Regulates Only the Neuritogenesis
Figure 5
Effects of inhibitors on the migration of cortical neurons. Inhibitors (shown below) of Src kinase (PP2) and Phospholipase Cγ activity (U2) inhibited the migration of fetal cortical neurons (Neurons/field) on laminin-(a) or fibronectin-(b) coated membranes (). No significant changes in the migration of neurons occurred in the presence of control compound PP3 or U3 (). Inhibitor of protein kinase C (light-activated Calphostin), inhibitor of IP3 mediated calcium release (2-APB), and intracellular calcium chelator (BAPTA-AM) inhibited the migration of neurons significantly () on laminin-(a) or fibronectin-(b) coated membranes. Ruthenium Red (inhibitor calcium-induced calcium release) and PD (inhibitor of Mitogen activated kinase kinase) did not alter the migration of neurons on laminin-(a) or fibronectin-(b) coated membranes ().
