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Neuroscience Journal
Volume 2013, Article ID 870608, 7 pages
Research Article

The Triglyceride Paradox in Stroke Survivors: A Prospective Study

1Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14627, USA
2Department of Emergency Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
3Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
4Department of Emergency Medicine, University of Rochester Medical Center, Rochester, NY 14627, USA
5Departments of Emergency Medicine and Neurological Surgery, University of Florida College of Medicine, Gainesville, FL 32608, USA

Received 14 October 2012; Revised 22 January 2013; Accepted 22 January 2013

Academic Editor: Pasquale Striano

Copyright © 2013 Minal Jain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The purpose of our study was to understand the association between serum triglycerides and outcomes in acute ischemic stroke (AIS) patients. Methods. A cohort of all adult patients presenting to the Emergency Department (ED) with an AIS from March 2004 to December 2005 were selected. The lipid profile levels were measured within 24 hours of stroke onset. Demographics, admission stroke severity (NIHSS), functional outcome at discharge (modified Rankin Scale (mRS)), and mortality at 3 months were recorded. Results. The final cohort consisted of 334 subjects. A lower level of triglycerides at presentation was found to be significantly associated with worse National Institutes of Health Stroke Scale (NIHSS) ( ), worse mRS ( ), and death at 3 months ( ). After adjusting for age and gender and NIHSS, the association between triglyceride and mortality at 3 months was not significant ( ). Conclusion. Lower triglyceride levels seem to be associated with a worse prognosis in AIS.