Table of Contents Author Guidelines Submit a Manuscript
Neuroscience Journal
Volume 2014, Article ID 370764, 6 pages
http://dx.doi.org/10.1155/2014/370764
Research Article

Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

1Institute of the Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Butlerova Street 5A, Moscow 117485, Russia
2Research and Educational Center “Nonlinear Dynamics of Complex Systems”, Saratov State Technical University, Saratov, Polytechnicheskaya Street 77, Saratov 410054, Russia
3Faculty of Nonlinear Processes, Saratov State University, Saratov, Astrakhanskaya Street 83, Saratov 410012, Russia
4Saratov State University, Astrakhanskaya Street 83, Saratov 410012, Russia

Received 28 April 2014; Revised 1 June 2014; Accepted 2 June 2014; Published 23 June 2014

Academic Editor: Pasquale Striano

Copyright © 2014 Evgenia Sitnikova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Steriade, Neuronal Substrates of Sleep and Epilepsy, Cambridge University Press, Cambridge, Mass, USA, 2003.
  2. L. de Gennaro and M. Ferrara, “Sleep spindles: an overview,” Sleep Medicine Reviews, vol. 7, no. 5, pp. 423–440, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Destexhe and T. J. Sejnowski, Thalamocortical Assemblies, Oxford University Press, Oxford, UK, 2001.
  4. P. Gloor, “Generalized epilepsy with bilateral synchronous spike and wave discharge. New findings concerning its physiological mechanisms,” Electroencephalography and Clinical Neurophysiology, no. 34, pp. S245–S249, 1978. View at Google Scholar · View at Scopus
  5. E. L. J. M. van Luijtelaar, “Spike-wave discharges and sleep spindles in rats,” Acta Neurobiologiae Experimentalis, vol. 57, no. 2, pp. 113–121, 1997. View at Google Scholar · View at Scopus
  6. G. K. Kostopoulos, “Spike-and-wave discharges of absence seizures as a transformation of sleep spindles: the continuing development of a hypothesis,” Clinical Neurophysiology, vol. 111, supplement 2, pp. S27–S38, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Leresche, R. C. Lambert, A. C. Errington, and V. Crunelli, “From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?” Pflugers Archiv European Journal of Physiology, vol. 463, no. 1, pp. 201–212, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Sitnikova, “Thalamo-cortical mechanisms of sleep spindles and spike-wave discharges in rat model of absence epilepsy (a review),” Epilepsy Research, vol. 89, no. 1, pp. 17–26, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Lüttjohann and G. van Luijtelaar, “The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy,” Neurobiology of Disease, vol. 47, no. 1, pp. 49–60, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Sitnikova, A. E. Hramov, A. A. Koronovsky, and G. van Luijtelaar, “Sleep spindles and spike-wave discharges in EEG: their generic features, similarities and distinctions disclosed with Fourier transform and continuous wavelet analysis,” Journal of Neuroscience Methods, vol. 180, no. 2, pp. 304–316, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Andrillon, Y. Nir, R. J. Staba et al., “Sleep spindles in humans: insights from intracranial EEG and unit recordings,” Journal of Neuroscience, vol. 31, no. 49, pp. 17821–17834, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Urakami, A. A. Ioannides, and G. K. Kostopoulos, “Sleep spindles—as a biomarker of brain function and plasticity,” in Advances in Clinical Neurophysiology, I . M. Ajeena, Ed., chapter 4, 2012. View at Google Scholar
  13. C. Iber, S. Ancoli-Israel, A. Chesson, and S. F. Quan, The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Technical Specification, American Academy of Sleep Medicine, Westchester, Ill, USA, 1st edition, 2007.
  14. G. Gandolfo, L. Glin, and C. Gottesmann, “Study of sleep spindles in the rat: a new improvement,” Acta Neurobiologiae Experimentalis, vol. 45, no. 5-6, pp. 151–162, 1985. View at Google Scholar · View at Scopus
  15. E. Sitnikova, A. E. Hramov, V. V. Grubov, and A. A. Koronovsky, “Time-frequency characteristics and dynamics of sleep spindles in WAG/Rij rats with absence epilepsy,” Brain Research, vol. 1543, pp. 290–299, 2014. View at Google Scholar
  16. E. I. Sitnikova, V. V. Grubov, A. E. Khramov, and A. A. Koronovskiǐ, “[Age-related changes in time-frequency structure of sleep spindles in EEG in rats with genetic predisposition to absence epilepsy (Wag/Rij)],” Zhurnal Vyssheǐ Nervnoǐ Deiatelnosti Imeni I P Pavlova, vol. 62, no. 6, pp. 733–744, 2012. View at Google Scholar · View at Scopus
  17. A. M. L. Coenen and E. L. J. M. van Luijtelaar, “Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats,” Behavior Genetics, vol. 33, no. 6, pp. 635–655, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. A. M. L. Coenen and E. L. J. M. van Luijtelaar, “The WAG/Rij rat model for absence epilepsy: age and sex factors,” Epilepsy Research, vol. 1, no. 5, pp. 297–301, 1987. View at Publisher · View at Google Scholar · View at Scopus
  19. G. van Luijtelaar and A. Bikbaev, “Midfrequency cortico-thalamic oscillations and the sleep cycle: genetic, time of day and age effects,” Epilepsy Research, vol. 73, no. 3, pp. 259–265, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Ovchinnikov, A. Lüttjohann, A. Hramov, and G. van Luijtelaar, “An algorithm for real-time detection of spike-wave discharges in rodents,” Journal of Neuroscience Methods, vol. 194, no. 1, pp. 172–178, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. E. I. Sitnikova, T. N. Egorova, and V. V. Raevskiǐ, “Reduction of the number of neurons in substantia nigra (Pars compacta) positively correlates with a reduction of seizure activity in WAG/Rij rats,” Zhurnal Vyssheǐ Nervnoǐ Deiatelnosti Imeni I P Pavlova, vol. 62, no. 5, pp. 619–628, 2012 (Russian). View at Google Scholar · View at Scopus
  22. N. Çarçak, R. G. Aker, O. Özdemir, T. Demiralp, and F. Y. Onat, “The relationship between age-related development of spike-and-wave discharges and the resistance to amygdaloid kindling in rats with genetic absence epilepsy,” Neurobiology of Disease, vol. 32, no. 3, pp. 355–363, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Steriade, “The corticothalamic system in sleep,” Frontiers in Bioscience, vol. 8, pp. d878–d899, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. S. V. Schönwald, D. Z. Carvalho, G. Dellagustin, E. L. de Santa-Helena, and G. J. L. Gerhardt, “Quantifying chirp in sleep spindles,” Journal of Neuroscience Methods, vol. 197, no. 1, pp. 158–164, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Z. Carvalho, G. J. Gerhardt, G. Dellagustin et al., “Loss of sleep spindle frequency deceleration in Obstructive Sleep Apnea,” Clinical Neurophysiology, vol. 125, pp. 306–312, 2014. View at Google Scholar