Change in Motor and Nonmotor Symptoms Severity in a “Real-Life” Cohort of Subjects with Parkinson’s Disease
Table 3
Comparison of mean scores for MDS-UPDRS, NMSS, and PDQ-8 between initial and follow-up visits according to disease severity.
Initial evaluation
Follow-up
value
MDS-UPDRS Part I
9.57 ± 6.17
9.11 ± 7.06
0.570
Mild
5.17 ± 2.33
4.96 ± 3.54
0.765
Moderate
15.11 ± 2.93
15.11 ± 2.80
≥0.99
Severe
22.00
33.00
—
MDS-UPDRS Part II
11.32 ± 8.12
11.32 ± 10.21
≥0.99
Mild
6.13 ± 3.88
5.58 ± 3.45
0.479
Moderate
18.50 ± 2.44
21.25 ± 5.17
0.185
Severe
38.00
44.00
—
MDS-UPDRS Part III
30.57 ± 16.01
23.40 ± 13.70
<0.001
Mild
21.23 ± 7.12
15.53 ± 7.23
<0.0001
Moderate
46.83 ± 7.93
38.83 ± 4.44
0.159
Severe
—
—
—
MDS-UPDRS Part IV
1.11 ± 2.30
2.02 ± 2.93
0.015
Mild
0.48 ± 1.16
0.93 ± 1.36
0.017
Moderate
9.50 ± 0.70
7.00 ± 0.00
0.126
Severe
—
—
—
MDS-UPDRS Total
51.45 ± 22.51
45.84 ± 27.84
0.068
NMSS
38.20 ± 38.96
52.48 ± 50.38
0.043
PDQ-8
21.88 ± 21.20
22.88 ± 20.11
0.575
Mean ± standard deviation. MDS-UPDRS: Movement Disorder Society Unified Parkinson’s Disease Rating Scale. NMSS: Nonmotor Symptom Assessment Scale for Parkinson’s Disease. PDQ-8: Parkinson’s Disease Quality of Life Questionnaire.
