Change in Motor and Nonmotor Symptoms Severity in a “Real-Life” Cohort of Subjects with Parkinson’s Disease
Table 4
Change in nonmotor symptoms scale score between initial and follow-up visits .
Domain
Initial evaluation
Follow-up
value
Cardiovascular
0.46 ± 1.16
1.02 ± 2.14
0.142
Mild
0.30 ± 1.19
0.34 ± 0.74
0.852
Moderate
0.75 ± 1.16
1.25 ± 2.76
0.598
Severe
0.00
9.00
—
Sleep/fatigue
6.33 ± 8.65
8.19 ± 8.44
0.141
Mild
2.50 ± 4.65
4.23 ± 4.99
0.095
Moderate
11.75 ± 8.54
12.50 ± 7.65
0.795
Severe
28.00
25.00
—
Mood/cognition
9.46 ± 14.40
12.40 ± 17.80
0.172
Mild
2.65 ± 6.80
5.53 ± 10.35
0.104
Moderate
14.00 ± 6.98
15.62 ± 18.11
0.787
Severe
18.00
62.00
—
Perceptual problems/hallucinations
0.17 ± 0.67
0.77 ± 2.10
0.044
Mild
0.07 ± 0.39
0.23 ± 0.86
0.425
Moderate
0.62 ± 1.40
1.12 ± 1.88
0.487
Severe
0.00
11.00
—
Attention
3.26 ± 6.00
5.09 ± 7.64
0.156
Mild
2.26 ± 4.03
3.11 ± 4.70
0.438
Moderate
8.12 ± 11.46
7.25 ± 10.89
0.782
Severe
2.00
36.00
—
Gastrointestinal tract
4.76 ± 6.37
5.56 ± 7.76
0.232
Mild
3.24 ± 4.90
3.00 ± 6.05
0.803
Moderate
4.87 ± 5.33
8.50 ± 8.41
0.280
Severe
12.00
30.00
—
Urinary function
6.17 ± 9.06
8.65 ± 10.94
0.240
Mild
2.72 ± 5.19
4.20 ± 6.53
0.389
Moderate
10.75 ± 11.75
11.75 ± 12.38
0.884
Severe
12.00
36.00
—
Sexual function
2.11 ± 4.69
3.83 ± 7.81
0.298
Mild
0.96 ± 2.38
2.04 ± 5.76
0.370
Moderate
4.87 ± 8.64
6.75 ± 9.37
0.654
Severe
0.00
24.00
—
Miscellaneous
4.80 ± 6.56
6.63 ± 6.38
0.112
Mild
3.24 ± 5.23
5.84 ± 6.13
0.117
Moderate
5.12 ± 4.82
5.37 ± 6.09
0.932
Severe
2.00
21.00
—
Total score
38.2 ± 38.96
52.48 ± 50.38
0.043
Mild
19.32 ± 23.77
28.68 ± 23.06
0.089
Moderate
60.87 ± 33.22
70.12 ± 43.41
0.606
Severe
74.00
254.00
—
Mean ± standard deviation. Each nonmotor symptom scale domain was subclassified according to the Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part I (Non-Motor Experiences of Daily Living) and cut-off values established by Martínez-Martín et al. [9].
