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Neuroscience Journal
Volume 2018, Article ID 4852359, 9 pages
Review Article

Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders

1Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA
2Candidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan
3Neuroscience, La Jolla Laboratory Astellas Research Institute of America, LLC. 3565 General Atomics Court, Suite 200, San Diego, CA 92121, USA

Correspondence should be addressed to Soichiro Nakahara;

Received 5 October 2017; Revised 2 December 2017; Accepted 20 December 2017; Published 22 January 2018

Academic Editor: Pasquale Striano

Copyright © 2018 Soichiro Nakahara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Accumulating evidence points to the association of epilepsy, particularly, temporal lobe epilepsy (TLE), with psychiatric disorders, such as schizophrenia. Among these illnesses, the hippocampus is considered the regional focal point of the brain, playing an important role in cognition, psychosis, and seizure activity and potentially suggesting common etiologies and pathophysiology of TLE and schizophrenia. In the present review, we overview abnormal network connectivity between the dentate gyrus (DG) and the Cornus Ammonis area 3 (CA3) subregions of the hippocampus relative to the induction of epilepsy and schizophrenia. In light of our recent finding on the misguidance of hippocampal mossy fiber projection in the rodent model of schizophrenia, we discuss whether ectopic mossy fiber projection is a commonality in order to evoke TLE as well as symptoms related to schizophrenia.