Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders

Figure 1

(a) Under normal conditions, mossy fibers and axons of granule cells target the SL region in the CA3 subfield, forming SPB. Contrastingly, a pathological condition occasionally results in ectopic mossy fiber projection, in which axons are guided not only to the SL, but also to the SO. (b) During postnatal development, both SPB and IPB are formed. Mossy fibers projected to the SO undergo retraction, thus leaving only SPB as they mature. (c) Presented are immune fluorescent staining of Znt-3 in the hippocampal sections. In α-CaMKII hKO mice, mossy fibers display robust projection onto the SO, developing IPB as indicated by arrowheads.

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