Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells
Figure 4
Photomicrographs of the prefrontal cortical regions in different groups of rats immunostained for β-amyloid protein (BAP). Note the expression of BAP (Arrow) in large number of neurons in AD group in all regions. The number of BAP positive neurons was less or not present in NAC treated groups (AD+NAC 100) (photomicrographs of sham and AD+NAC 50 groups are avoided for simplicity). Scale bar= 25μ. Graph shows quantitative estimation of number of neurons expressing BAP in frontal cortical regions. In all regions 300μ2 area was selected for quantification. Note that, in all regions, number of neurons expressing BAP significantly increased in AD and AD+ NAC 50, AD+NAC 100 groups compared to control group. Values are expressed as mean ± SE. Control/sham versus AD: ∗∗∗, p<0.001; control/sham versus AD+NAC50; or control/sham versus AD+NAC100: $$$, p<0.001 (one-way ANOVA, Bonferroni’s multiple comparison test, and n=6 in all groups). MFC-Media prefrontal cortex, OFC-Orbital prefrontal cortex, and LFC-Lateral prefrontal cortex.