Functional effects of KCNE1 and KCNE3 on KCNQ1. KCNQ1, KCNQ1-KCNE1, and KCNQ1-KCNE3 currents in response to 3 s pulses to a range of voltages between −120 mV and +60 mV, with 10 s interpulse intervals, from a holding voltage of −80 mV, with a 1 s −30 mV tail pulse, as shown in voltage protocol (upper center). Channels were expressed by injection of corresponding cRNAs into Xenopus laevis oocytes and currents recorded 3 days after injection by two-electrode voltage-clamp. Zero current levels indicated by dashed lines.
