Macrophages, Neutrophils, and Cancer: A Double Edged Sword

Table 1

Effector molecules involved in tumor promotion by TAM.

Molecules	Effect	Selected reference
EGF, bFGF,	Tumor Growth	Condeelis and Pollard, 2006 [4]
		Mantovani and Sica, 2010 [97]
Cathepsins, MMP-2, MMP-9	ECM Remodeling, Tumor Invasion, Metastasis	Gocheva et al., 2010 [98]
SR-A		Nagakawa et al., 2002 [99]
TGF-		Neyen et al., 2013 [100]
LL37		Ye et al., 2012 [101]
		Li et al., 2013 [102]
MMP9	Angiogenesis and Lymphangiogenesis	Huang et al., 2002 [103]
VEGFs		Granata et al., 2010 [104]
PDGF		Wang et al., 2011 [105]
CXCL8		Hotchkiss et al., 2003 [106]
		Murdoch et al., 2008 [107]
IDO	Immunosuppression	Zhao, et al., 2012 [146]
IL-10		Sica et al., 2000 [108]
TGF-		Hagemann et al., 2006 [109]
B7-H1 (PD-L1)		Kuang et al., 2009 [110]
B7-H3		Chen et al., 2013 [111]
B7-H4		Chen et al., 2012 [112]
Arginine Depletion		Chang et al., 2001 [113]